Author: heejeongryu

Towards computational, algorithmic and implementation level understanding of perceptual inference

Abstract Mechanisms underlying pathogenesis of metabolic dysfunction-associated steatotic liver disease (MASLD) KyeongJin Kim Departments of Biomedical Sciences, College of Medicine; Program in Biomedical Science & Engineering; Research Center for Controlling Intercellular Communication (RCIC), Inha University, Incheon 22212, Korea Obesity predisposes to type 2 diabetes (T2D) and metabolic dysfunction-associated steatotic liver disease (MASLD), but...

Towards computational, algorithmic and implementation level understanding of perceptual inference

Abstract When sensory information is incomplete or ambiguous, the brain relies on prior expectations to infer perceptual objects. Despite the centrality of this process to perception, the neural mechanism of sensory inference is not known. Illusory contours (ICs) are key tools to study sensory inference because...

Suboptimal Paths in Medicine

We all behave: patients, clinicians, everyone. In most clinical practices, the states and conditions of clinical situations change sequentially. We can define a trajectory to characterize a patient’s health status. Clinicians strive to improve a patient's health through timely interactions, which include ordering laboratory tests,...

Decoding Exercise at Molecular Levels and Health

3D Imaging and Optogenetic Pacing of in Vitro and in Vivo Model Systems

Robust and scalable single-molecule protein sequencing with fluorosequencing

Abstract The need to accurately survey proteins and their modifications with ever higher sensitivities, particularly in clinical settings with limited samples, is spurring development of new single molecule proteomics technologies. Here, we describe our optimization of one such highly parallelized single molecule peptide sequencing platform, fluorosequencing,...

Unravelling atopic dermatitis and psoriasis using single cell Rnaseq

Unravelling atopic dermatitis and psoriasis using single cell Rnaseq   Seunghee Hong Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, Republic of Korea   Atopic dermatitis (AD) and psoriasis are prevalent chronic inflammatory skin diseases primarily mediated by T cells, often managed with cytokine antagonists or...

Scalable single nucleus RNA sequencing of heavily-fixed or FFPE tissues by fixative exchange (FX)-seq

Scalable single nucleus RNA sequencing of heavily-fixed or FFPE tissues by fixative exchange (FX)-seq Chang Ho Sohn Yonsei University   Recent advances in single cell analyses by next-generation sequencing have broaden our understanding about how complex biological systems work at single cell level. Yet, current single cell RNA sequencing...