Seminar Abstract Tissue regeneration is a multi-step process mediated by diverse cellular hierarchies and states that are also implicated in tissue dysfunction and pathogenesis. Tissue injury instigates an inflammatory response by modulating immune system in the wound sites, which is essential for restoration of tissue...
Simultaneous profiling of 3D genome structure and DNA methylation in single human cells Dynamic three-dimensional chromatin conformation is a critical mechanism for gene regulation during development and disease. Despite this, profiling of three-dimensional genome structure from complex tissues with cell-type specific resolution remains challenging. Recent efforts...
Structure prediction with AlphaFold2 is set to have a huge impact on biology, medicine, and biotechnology. AlphaFold2 is not only accurate but, if optimized, also fast. Our ColabFold-AlphaFold2 pipeline accurately predicts the structures of a whole proteome within two days on a single GPU, approx....
