SEMINAR

Recreation of 3D microenvironment for stem cell differentiation

Yoonhee Jin
Dept. Physiology, Yonsei University College of Medicine
yoonheejin@yuhs.ac

For the last decades, tremendous efforts have been made to artificially recreate counterparts of in vivo organs from their tissues or cells. Only in the recent years has organoid technology as a whole technological field systematically emerged and been shown to be a key factor in tissue engineering. Based on their self-organizing properties, stem cells from various organs, both harvested and induced, can form 3D structures that are structurally and physiologically similar to the native organs in remarkable detail. The organoid-based model a powerful platform for elucidating the development mechanisms, modelling diseases, and drug discovery. In this talk, I will summarize the advances of this technology for generating various organoids of tissues, discuss current limitations and prospects for tissue engineering.